Orlistat--a novel weight loss therapy (Patel et al., 2002). Although it has been reported that both low‐carbohydrate diets and moderate‐to‐high‐protein, low‐fat can result in significant weight loss, loss from these diets may be offset by increased energy intake (Petersen, 2003). This may be particularly true for individuals with severe obesity. A high‐protein, low‐fat diet may provide more than the low‐carbohydrate diet in terms of weight loss, but it also has the potential to result in significant excess weight gain. For these reasons, there is the potential for an increased risk of weight regain if the loss achieved through a high‐protein diet is not sustained, even at the end of treatment. What effects does protein have on body composition? Research on the effect of protein body composition is limited and only a few studies have been done to date. Two studies that have attempted to compare the effects of protein with that carbohydrate on body composition have been undertaken. The first study involved a diet high in protein (∼75 g/day) and low in carbohydrate (∼40 g/day) when compared to a control diet (Wald et al., 1980), resulting in a weight loss of ∼5 kg. A second study involved high‐protein diet, and a diet low in protein and high carbohydrate (∼60 g/day) when compared to a carbohydrate‐restricted diet (Wald et al., 2006). In this study, weight loss between 8 and 12 kg was achieved with the high‐protein diet, no significant differences in body weight between the two diet groups. Given the limited evidence that protein can have a positive effect on body composition, the of protein intake on body composition in response to dietary interventions is likely be small. Therefore, it is important to monitor the effect of dietary protein on body weight and composition. Are there any long‐term clinical effects of dietary protein intake? The effects of dietary protein on body weight are modest in the short term and short‐term. In the short term, excess weight may be retained, but it is unlikely to be maintained. A review of the literature conducted in 2002 and published the Annals of Nutrition and Metabolism concluded that the most important effect of dietary protein appears to be due satiety and not to changes in body composition (Dinan et al., 2002). The effect of dietary protein on body composition with weight loss in the long term is unknown. There good evidence that high‐protein diets reduce gastric emptying (Wald et al., 2006), but the effect of dietary protein on body composition at 12 months after the intervention in above two studies is not clear. The authors of review suggest that future research is needed to show whether protein has a significant effect on body composition over a longer period of time and whether there are long‐term effects of high‐protein diets in healthy individuals. What is the impact of protein intake on bone health? There is a paucity of evidence on the effect dietary protein bone health. Two studies have investigated the effect of dietary protein on bone health in healthy people. the first study, subjects on a low‐protein diet gained more bone than those on a diet high in protein (Wald et al., 1990). However, this study was small, and the group contained individuals with osteoporosis. The second study was undertaken to determine whether consumption of high‐protein foods can increase bone mass in adults (Rice et al., 2005). This study included an age‐ and height‐matched groups, in which the groups were Order real phentermine 37.5 fed either a protein‐rich diet or high‐carbohydrate for 8 weeks. Despite the higher protein intake, both high‐protein and the high‐carbohydrate groups lost bone mass and the study did not have sufficient numbers to enable conclusions be drawn. However, further research is required to determine the effect of dietary Temazepam 30 mg for sale protein on bone health. Is protein harmful for the elderly? The recent popularity of vegetarian and vegan diets, particularly among the elderly, has resulted in controversy. Some individuals use vegetarian or vegan diets to achieve energy balance and lose weight; however, vegetarian diets are usually high in fat and low protein. This results in a higher protein intake, which is also low in calcium and phosphorus. This may result in increased risk of bone loss and a lower mass (Sato et al., 2003). A moderate protein diet for adult women (∼25% of energy from protein), when compared to a high protein diet in healthy adults (∼40% of energy from protein), results in ∼50% of the energy from protein as fat (Gibson and Hirsch, 1996). Further, calcium phosphorus intakes are higher with low‐protein diets than high‐protein in healthy adults (Gibson et al., 1996). A study by Paddon‐Jones et al. (2001)
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